PRESENTATION
DARBEPRO 40 (Darbepoetin Alpha 40 mcg PFS) is available as 0.40 ml Single Dose Pre-Filled Syringe
DESCRIPTION
DARBEPRO 40 (Darbepoetin Alpha 40 mcg/0.40 ml PFS) is an erythropoiesis stimulating protein that is produced in Chinese Hamster Ovary (CHO). It is a 165 amino acid protein that differs from rHuEPO in containing 5 N- linked oligosaccharide chains, where as repo contains 3chains. The 2 additional N-glycosylation sites result from amino acid substitution in erythropoietin peptide backbone. The approximate molecular weight of Darbepoetin Alpha is 37,000 daltons.
INDICATIONS & USAGE
Treatment of anemia due to chronic kidney disease
Treatment of anemia due to cancer chemotherapy
DOSAGE & ADMINISTRATION
For correction of anemia in CKD
Initial dose is 0.45 mcg/kg body weight once in a week, which can be titrated upto 1.5 mcg/kg body weight in a month in divided doses.
For correction of anemia in cancer chemotherapy
The recommended initial doses: 2.25 mcg/kg every week until completion of chemotherapy course or 500 mcg/kg every three weeks until completion of chemotherapy course.
ADMINISTRATION
To be administered Subcutaneous or Intravenous route only.
STORAGE
To be stored in between (2 - 8°C) only. Do not freeze.
CONTRAINDICATION
Uncontrolled hypertension
Known hypersensitivity to any active substance or its excipients
Pure Red Cell Aplasia (PRCA)R
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